心力衰竭的现行和新型肾脏生物标志物。
Current and novel renal biomarkers in heart failure.
机构信息
Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
出版信息
Heart Fail Rev. 2012 Mar;17(2):241-50. doi: 10.1007/s10741-011-9254-2.
Abstract
Renal function is the most important predictor of clinical outcome in heart failure (HF). It is therefore essential to have accurate and reliable measurement of renal function and early specific markers of renal impairment in patients with HF. Several renal functional entities exist, including glomerular filtration (GFR), glomerular permeability, tubulointerstitial damage, and endocrine function. Different markers have been studied that can be used to determine changes and the effect of treatment in these entities. In the present review, we summarize current and novel markers that give an assessment of renal function and prognosis in the setting of acute and chronic HF.
摘要
肾功能是心力衰竭（HF）临床结局的最重要预测因子。因此，对于 HF 患者，准确可靠地测量肾功能和早期特定的肾功能损害标志物至关重要。存在几种肾功能实体，包括肾小球滤过（GFR）、肾小球通透性、肾小管间质损伤和内分泌功能。已经研究了不同的标志物，可用于确定这些实体中变化和治疗效果。在本综述中，我们总结了当前和新型标志物，可用于评估急性和慢性 HF 中的肾功能和预后。
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