Nuclear Medicine Department, University Hospital of Brest, Brest, France.
Head Neck. 2012 Apr;34(4):462-8. doi: 10.1002/hed.21765. Epub 2011 May 20.
High tumor uptake of fluorodeoxyglucose (FDG) is associated with an unfavorable outcome in patients with cancer. We evaluated FDG uptake as a prognostic factor in patients with head and neck squamous cell carcinoma.
Maximum standardized uptake values (SUVmax) of tumor, liver, and pulmonary artery were recorded. Ratios of SUVmax from tumor to liver (T/L) and from tumor to pulmonary artery (T/PA) were calculated for each patient. Clinical data, tumor, and SUVmax ratios were compared with disease-free survival (DFS) and overall survival (OS).
Eighty-nine patients were included: 48 presented a local recurrent disease or distant metastases and 42 died. For both DFS and OS, tumor SUVmax value of 7 was the best cutoff value and 4 and 5 for T/L and T/PA ratios. Multivariate analysis confirmed the independent prognostic value of these 3 thresholds for DFS and OS.
FDG uptake has a significant and independent relationship with recurrence and survival.
氟脱氧葡萄糖（FDG）在肿瘤中的高摄取与癌症患者的不良预后相关。我们评估了 FDG 摄取作为头颈部鳞状细胞癌患者的预后因素。
记录肿瘤、肝脏和肺动脉的最大标准化摄取值（SUVmax）。为每位患者计算肿瘤与肝脏（T/L）和肿瘤与肺动脉（T/PA）的 SUVmax 比值。将临床数据、肿瘤和 SUVmax 比值与无病生存率（DFS）和总生存率（OS）进行比较。
共纳入 89 例患者：48 例出现局部复发性疾病或远处转移，42 例死亡。对于 DFS 和 OS，肿瘤 SUVmax 值为 7 是最佳截断值，而 T/L 和 T/PA 比值分别为 4 和 5。多变量分析证实了这 3 个阈值对 DFS 和 OS 的独立预后价值。
FDG 摄取与复发和生存具有显著的独立关系。
