Department of Transplantation, Lahey Clinic, Burlington, MA 01805, USA.
Liver Transpl. 2011 Oct;17(10):1226-33. doi: 10.1002/lt.22342.
All right hepatic lobe (RHL) donors in our program are asked to participate in a longitudinal quality-of-life study that begins at their evaluation and continues throughout the first postdonation year. Here we report the characteristics of donor candidates who completed the donation process despite ambivalence. In all, 183 RHL candidates consented, and 133 became donors. Ambivalent donors (ADs; n = 45) identified themselves through verbal statements or written comments, or they were identified by staff during the evaluation. ADs were predominantly male (73.3%), were older than unambivalent donors (UADs; >35 years: 76% of ADs versus 53% of UADs, P = 0.008), and were well educated (college graduate: 60% of ADs versus 17% of UADs, P = 0.01). Brother-to-brother and son-to-father combinations were most common among ADs. Alcohol (22% versus 11%, P = 0.04) and hepatitis C virus (51% versus 27%, P = 0.008) were more common as disease etiologies for recipients with ADs versus recipients with UADs. More ADs than UADs considered themselves to be religious (68.9% versus 43.2%, P = 0.007). Ambivalence about RHL donation was present in 33.8% of the candidates who completed the donation process. These results suggest that ambivalence should not be the sole reason for disqualifying a potential donor who otherwise satisfies program requirements.
所有参与我们项目的右半肝供体（RHL）捐献者都被要求参加一项从评估开始并持续整个首次捐献后一年的纵向生活质量研究。在这里，我们报告了尽管存在矛盾但仍完成捐献过程的供体候选人的特征。共有 183 名 RHL 候选者同意参与，其中 133 名成为供体。矛盾型供体（AD；n=45）通过口头陈述或书面评论自我认定，或在评估期间被工作人员认定。AD 主要为男性（73.3%），年龄大于非矛盾型供体（UAD；>35 岁：AD 中的 76%比 UAD 中的 53%，P=0.008），且受教育程度较高（大学毕业：AD 中的 60%比 UAD 中的 17%，P=0.01）。兄弟对兄弟和父子对父子组合在 AD 中最为常见。AD 供体的受体中，酒精（22%比 11%，P=0.04）和丙型肝炎病毒（51%比 27%，P=0.008）作为疾病病因更为常见。与 UAD 供体相比，更多的 AD 供体认为自己是宗教人士（68.9%比 43.2%，P=0.007）。在完成捐献过程的候选者中，有 33.8%的人对 RHL 捐献存在矛盾。这些结果表明，对于其他方面符合项目要求的潜在供体，不应仅因存在矛盾而取消其资格。
