Bi Jicai, Wang Honghai, Xie Jianping
Institute of Modern Biopharmaceuticals, School of Life Sciences,Southwest University, Chongqing 400715, China.
Wei Sheng Wu Xue Bao. 2011 Mar;51(3):305-12.
Nicotinamide-adenine dinucleotide (phosphate) (NAD(P)) metabolism involves many fundamental cellular events, such as energy metabolism, maintenance of redox homeostasis and regulation of cell longevity. Inhibitors of essential enzymes of NAD(P) biosynthetic pathways might be promising leads for novel antibiotics, such as the NAD synthase inhibitors. This review described the crystal structural, functional properties, regulator and structure-based inhibitors design for NAD synthase. This might provide the basis for developing NAD-based therapeutics.
烟酰胺腺嘌呤二核苷酸（磷酸）（NAD(P)）代谢涉及许多基本的细胞活动，如能量代谢、氧化还原稳态的维持以及细胞寿命的调节。NAD(P)生物合成途径中关键酶的抑制剂可能是新型抗生素的有前景的先导物，如NAD合酶抑制剂。本文综述了NAD合酶的晶体结构、功能特性、调节剂以及基于结构的抑制剂设计。这可能为开发基于NAD的治疗方法提供基础。
