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右叶活体肝供体并发症分析:单中心经验

Analysis of right lobe living-liver donor complications: a single center experience.

作者信息

Yaprak Onur, Dayangac Murat, Demirbas B Tolga, Tabendeh Babek, Yuzer Yildiray, Tokat Yaman

机构信息

Florence Nightingale Hospital, Hepato-Biliary and Organ Transplant Center, Istanbul, Turkey.

出版信息

Exp Clin Transplant. 2011 Feb;9(1):56-9.

Abstract

OBJECTIVES

Living-donor liver transplant provides an alternative source of organ to patients with end-stage liver disease. This study sought to determine and classify the donor morbidities after right lobe donor hepatectomy in a single center.

MATERIALS AND METHODS

One hundred eighty-one right lobe living-donor hepatectomy were performed in our center between January 2004 and December 2009. Of the 181 donors, 104 donors were men and 77 donors were women. Mean age of the donors was 38 years (range, 18-63 years). The mean follow-up was 33.3 months (range, 3-66 months). Complications after the operation were stratified according to the Clavien classification.

RESULTS

Eighty-one complications occurred in 73 of the 181 donors (40.3%). The most common complication was wound infection, which was seen in 14 of 181 donors (7.7%). Biliary complications were seen in 4.4% of donors. There was no postoperative mortality. Also, grade 4 complications, which are life-threatening, did not occur. Blood transfusion were not required during the operation. The incidence of reoperation was 1.6% in all donors.

CONCLUSIONS

Living-donor liver transplant ensures a new graft to patients with end-stage liver disease. Donor morbidity is one of the realities of the donor hepatectomy procedure. Because the donors are healthy individuals, the aim of the process must be to eliminate the donor mortality while decreasing the complication rates.

摘要

目的

活体肝移植为终末期肝病患者提供了一种器官来源。本研究旨在确定并分类单中心右半肝供肝切除术后供体的并发症。

材料与方法

2004年1月至2009年12月期间,我们中心共进行了181例右半肝活体供肝切除术。在这181例供体中,男性104例,女性77例。供体的平均年龄为38岁(范围18 - 63岁)。平均随访时间为33.3个月(范围3 - 66个月)。术后并发症根据Clavien分类进行分层。

结果

181例供体中的73例(40.3%)出现了81种并发症。最常见的并发症是伤口感染,181例供体中有14例(7.7%)出现该情况。4.4%的供体出现了胆道并发症。无术后死亡病例。此外,未发生危及生命的4级并发症。手术过程中无需输血。所有供体的再次手术发生率为1.6%。

结论

活体肝移植为终末期肝病患者提供了新的移植物。供体并发症是供肝切除手术的现实情况之一。由于供体是健康个体,该过程的目标必须是消除供体死亡,同时降低并发症发生率。

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