Petramfar Peyman, Yousefian Marzieh, Ashraf Mohammad Hosein, Davarpanah Mohammad Ali, Rahmati Hashem
Neurology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
Exp Clin Transplant. 2011 Feb;9(1):68-71.
We report a case of central nervous system coinfection with 2 types of opportunistic organisms-Aspergillus and Mycobacterium tuberculosis-in a 33-year-old woman who underwent a renal transplant.
She developed a high-grade fever and right-sided weakness 1 month after the transplant while on mycophenolate mofetil, prednisolone, and cyclosporine.
Brain magnetic resonance imaging revealed multiple mass lesions with peripheral ring enhancement. Colony-stimulating factor polymerase chain reaction was positive for Aspergillus and Mycobacterium tuberculosis.
Broad-spectrum antibiotics, antituberculous agents, and amphotericin were started. Unfortunately, the woman's condition deteriorated, and she died 2 weeks after admission to the hospital.
我们报告一例33岁接受肾移植的女性中枢神经系统同时感染两种机会性致病菌——曲霉菌和结核分枝杆菌的病例。
移植术后1个月，她在服用霉酚酸酯、泼尼松龙和环孢素期间出现高热和右侧肢体无力。
脑磁共振成像显示多个有外周环形强化的肿块性病变。集落刺激因子聚合酶链反应检测曲霉菌和结核分枝杆菌呈阳性。
开始使用广谱抗生素、抗结核药物和两性霉素。不幸的是，该女性病情恶化，入院2周后死亡。
