Institute of Clinical Pharmacology and Visceral Research, University of Bern, Murtenstrasse 35, Bern, Switzerland.
Curr Pharm Biotechnol. 2012 Sep;13(11):2221-7. doi: 10.2174/138920112802502097.
Apoptosis is a rare event in normal hepatocytes. However, multiple signals can trigger apoptosis in hepatocytes and it plays a role in the pathogenesis of many liver diseases. This review summarizes the mechanisms of hepatocellular apoptosis and the importance of apoptosis in the pathological processes of liver disease. The potential for non-invasive biomarkers of apoptosis to gauge the extent and follow the evolution of clinical disease is emphasized.
细胞凋亡在正常肝细胞中很少发生。然而，多种信号可以触发肝细胞凋亡，它在许多肝病的发病机制中起作用。这篇综述总结了肝细胞凋亡的机制以及凋亡在肝病病理过程中的重要性。强调了非侵入性凋亡生物标志物在评估疾病严重程度和跟踪临床疾病演变方面的潜力。
