Department of Clinical Sciences, Section for Paediatrics, The BUT team, Lund University, Sweden.
Acta Paediatr. 2011 Nov;100(11):1448-53. doi: 10.1111/j.1651-2227.2011.02361.x. Epub 2011 Jun 15.
To expand the treatment options in paediatric Gorham-Stout syndrome (GSS) when conventional therapy is ineffective.
Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon-α-2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery.
The combined therapy resolved the symptoms in the acute phase, and both patients have since been free of symptoms for >2 years.
The successful addition of a low anticoagulant, low molecular weight heparin (tafoxiparin) to the treatment protocol in two paediatric cases of the GSS may justify the use of this approach in similar cases.
当常规治疗无效时，为儿科 Gorham-Stout 综合征（GSS）患者提供更多治疗选择。
对 2 例经活检证实为 GSS 的儿童患者（一种罕见的进行性淋巴管瘤病）采用干扰素-α-2b、低抗凝剂、低分子肝素、放疗和手术联合治疗。
联合治疗缓解了急性期症状，且两名患者此后均无任何症状超过 2 年。
在 2 例儿科 GSS 患者的治疗方案中成功添加低抗凝剂、低分子肝素（tafoxiparin）可能证明该方法在类似病例中的应用是合理的。
