截短的病毒反式激活蛋白对组蛋白H2B基因转录和细胞生长的抑制作用。
Inhibition of histone H2B gene transcription and of cellular growth by a truncated viral trans-activator protein.
作者信息
Dent C L, Estridge J K, Kemp L M, Latchman D S
机构信息
Department of Biochemistry, University College and Middlesex School of Medicine, London, United Kingdom.
出版信息
Mol Cell Biol. 1990 Jun;10(6):3258-61. doi: 10.1128/mcb.10.6.3258-3261.1990.
Abstract
The herpes simplex virus virion protein Vmw65 trans activates the viral immediate-early genes and some octamer-containing cellular genes, including that encoding histone H2B. We found, however, that a truncated form of this virion protein repressed H2B gene transcription and also dominantly inhibited induction of the gene by intact Vmw65. A cell line expressing this truncated protein expressed reduced levels of H2B and grew more slowly than the parental cell line or a similar line expressing the intact protein.
摘要
单纯疱疹病毒病毒体蛋白Vmw65可反式激活病毒的立即早期基因以及一些含八聚体的细胞基因，包括编码组蛋白H2B的基因。然而，我们发现这种病毒体蛋白的截短形式会抑制H2B基因的转录，并且还会显性抑制完整的Vmw65对该基因的诱导作用。表达这种截短蛋白的细胞系中H2B水平降低，且其生长速度比亲代细胞系或表达完整蛋白的类似细胞系更慢。
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1
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2
Identification of promoter elements necessary for transcriptional regulation of a human histone H4 gene in vitro.体外鉴定人组蛋白H4基因转录调控所需的启动子元件。
Mol Cell Biol. 1985 Feb;5(2):380-9. doi: 10.1128/mcb.5.2.380-389.1985.
3
Negative effect of the transcriptional activator GAL4.转录激活因子GAL4的负面影响。
Nature. 1988 Aug 25;334(6184):721-4. doi: 10.1038/334721a0.
4
Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element.
Genes Dev. 1988 Jan;2(1):32-9. doi: 10.1101/gad.2.1.32.
5
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Nature. 1988 Oct 20;335(6192):683-9. doi: 10.1038/335683a0.
6
GAL4-VP16 is an unusually potent transcriptional activator.GAL4-VP16是一种异常强效的转录激活因子。
Nature. 1988 Oct 6;335(6190):563-4. doi: 10.1038/335563a0.
7
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8
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9
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