促肾上腺皮质激素/促黑素（4-10）肽在产前早期给药后可增加出生后趾长伸肌的代谢活性。

ACTH/MSH(4-10) peptide increases postnatal metabolic activity of EDL muscle following early prenatal administration.

作者信息

Rose K J, Strand F L

机构信息

Department of Biology, New York University, New York 10003.

出版信息

Peptides. 1990 Jan-Feb;11(1):177-9. doi: 10.1016/0196-9781(90)90128-r.

DOI:10.1016/0196-9781(90)90128-r

PMID:2160650

Abstract

ACTH/MSH(4-10) (10 micrograms/kg/b.i.d.; IP), administered to pregnant Sprague-Dawley rats during gestational days (GD) 3 to 12, significantly increased the metabolic activity of extensor digitorum longus (EDL) muscle at postnatal day 14. ACTH/MSH peptide, administered from day of birth to postnatal day 13, had no effect on EDL muscle metabolic activity using the 2,3,5-triphenyltetrazolium chloride indicator. By postnatal day 30, no differences were seen between the early prenatally treated group and saline controls. These results confirm our previous electrophysiological studies that showed that early prenatal ACTH/MSH(4-10) administration accelerates EDL muscle maturation.

摘要

在妊娠第3至12天给怀孕的斯普拉格-道利大鼠腹腔注射促肾上腺皮质激素/促黑素(4 - 10)(10微克/千克/每日两次)，显著提高了出生后第14天的趾长伸肌(EDL)的代谢活性。从出生到出生后第13天给予促肾上腺皮质激素/促黑素肽，使用2,3,5 - 三苯基氯化四氮唑指示剂，对EDL肌肉代谢活性没有影响。到出生后第30天，早期产前治疗组和生理盐水对照组之间没有差异。这些结果证实了我们之前的电生理研究，即早期产前给予促肾上腺皮质激素/促黑素(4 - 10)可加速EDL肌肉成熟。