Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Autophagy. 2011 Sep;7(9):1085-7. doi: 10.4161/auto.7.9.16465. Epub 2011 Sep 1.
In kidney, proximal tubules consume a large amount of energy in the process of electrolyte reabsorption. These tubules contain large quantities of mitochondria which provide the energy for this reabsorption. Proximal tubules are susceptible to many kinds of insults such as ischemia-reperfusion injury and nephrotoxic substrates, but little is known of the factors that counteract cellular stress signaling pathways. Autophagy mediates bulk degradation and recycling of cytoplasmic constituents to maintain cellular homeostasis. We demonstrated the critical role of autophagy in normal proximal tubule function and protection against acute tubular injury.
在肾脏中，近端小管在电解质重吸收的过程中消耗大量能量。这些小管含有大量的线粒体，为重吸收提供能量。近端小管容易受到多种损伤，如缺血再灌注损伤和肾毒性底物，但对抗细胞应激信号通路的因素知之甚少。自噬介导细胞质成分的批量降解和回收，以维持细胞内稳态。我们证明了自噬在正常近端小管功能和防止急性肾小管损伤中的关键作用。
