通过外显子组测序鉴定的急性早幼粒细胞白血病（APL）中的体细胞突变。 - Suppr

Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing.

作者信息

Greif P A, Yaghmaie M, Konstandin N P, Ksienzyk B, Alimoghaddam K, Ghavamzadeh A, Hauser A, Graf A, Krebs S, Blum H, Bohlander S K

出版信息

Leukemia. 2011 Sep;25(9):1519-22. doi: 10.1038/leu.2011.114. Epub 2011 May 24.

DOI:10.1038/leu.2011.114

PMID:21606962

Abstract

摘要

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Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing.通过外显子组测序鉴定的急性早幼粒细胞白血病（APL）中的体细胞突变。

Leukemia. 2011 Sep;25(9):1519-22. doi: 10.1038/leu.2011.114. Epub 2011 May 24.

The Mutational Landscape of Acute Promyelocytic Leukemia Reveals an Interacting Network of Co-Occurrences and Recurrent Mutations.急性早幼粒细胞白血病的突变图谱揭示了共现和复发性突变的相互作用网络。

PLoS One. 2016 Feb 17;11(2):e0148346. doi: 10.1371/journal.pone.0148346. eCollection 2016.

Occurrence of distinct PML-RAR-alpha fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction.通过逆转录酶/聚合酶链反应检测急性早幼粒细胞白血病患者中不同的PML-RAR-α融合基因异构体的出现情况。

Oncogene. 1992 Jun;7(6):1223-32.

HLA-DRneg patients without acute promyelocytic leukemia show distinct immunophenotypic, genetic, molecular, and cytomorphologic characteristics compared to acute promyelocytic leukemia.与急性早幼粒细胞白血病相比，非急性早幼粒细胞白血病的HLA - DR阴性患者表现出独特的免疫表型、遗传、分子和细胞形态学特征。

Cytometry B Clin Cytom. 2009 Sep;76(5):321-7. doi: 10.1002/cyto.b.20475.

Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): a retrospective study from the European APL Group.急性早幼粒细胞白血病（APL）患者中FLT3和Ras基因突变的预后意义：来自欧洲APL协作组的一项回顾性研究

Leukemia. 2005 Jul;19(7):1153-60. doi: 10.1038/sj.leu.2403790.

Clinico-biological features and outcome of acute promyelocytic leukemia patients with persistent polymerase chain reaction-detectable disease after the AIDA front-line induction and consolidation therapy.急性早幼粒细胞白血病患者在接受AIDA一线诱导和巩固治疗后仍存在聚合酶链反应可检测疾病的临床生物学特征及预后

Haematologica. 2004 Jan;89(1):29-33.

[Detection of the PML/RAR alpha rearrangement in acute promyelocytic leukemia using a reverse PCR method].[运用逆转录聚合酶链反应方法检测急性早幼粒细胞白血病中的PML/RARα重排]

Sangre (Barc). 1996 Jun;41(3):189-94.

Rearrangement of the retinoic acid receptor gene in acute promyelocytic leukemia.

Leukemia. 1991 Mar;5(3):200-4.

[Prevalence and clinical significance of FLT3 mutations in acute promyelocytic leukemia].[急性早幼粒细胞白血病中FLT3突变的患病率及临床意义]

Zhonghua Xue Ye Xue Za Zhi. 2008 Nov;29(11):757-61.

Missense mutations in the PML/RARalpha ligand binding domain in ATRA-resistant As(2)O(3) sensitive relapsed acute promyelocytic leukemia.全反式维甲酸耐药但三氧化二砷敏感的复发性急性早幼粒细胞白血病中PML/RARα配体结合域的错义突变

Haematologica. 1999 Nov;84(11):963-8.

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6-Gingerol modulates miRNAs and PODXL gene expression via methyltransferase enzymes in NB4 cells: an in silico and in vitro study.6-姜酚通过 NB4 细胞中的甲基转移酶调节 miRNA 和 PODXL 基因的表达：一项计算机模拟和体外研究。

Sci Rep. 2024 Aug 7;14(1):18356. doi: 10.1038/s41598-024-68069-4.

Uncovering novel mutational signatures by extraction with SigProfilerExtractor.通过SigProfilerExtractor提取来揭示新的突变特征。

Cell Genom. 2022 Nov 9;2(11):None. doi: 10.1016/j.xgen.2022.100179.

Cytogenetics analysis as the central point of genetic testing in acute myeloid leukemia (AML): a laboratory perspective for clinical applications.细胞遗传学分析作为急性髓系白血病（AML）基因检测的核心要点：临床应用的实验室视角

Clin Exp Med. 2023 Aug;23(4):1137-1159. doi: 10.1007/s10238-022-00913-1. Epub 2022 Oct 13.

A comprehensive review of genetic alterations and molecular targeted therapies for the implementation of personalized medicine in acute myeloid leukemia.急性髓系白血病中实施个性化医学的遗传改变和分子靶向治疗的全面综述。

J Mol Med (Berl). 2020 Aug;98(8):1069-1091. doi: 10.1007/s00109-020-01944-5. Epub 2020 Jul 3.

Identification of a novel functional JAK1 S646P mutation in acute lymphoblastic leukemia.急性淋巴细胞白血病中一种新型功能性JAK1 S646P突变的鉴定

Oncotarget. 2017 May 23;8(21):34687-34697. doi: 10.18632/oncotarget.16670.

Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia.初发及复发急性早幼粒细胞白血病的全面突变分析

Leukemia. 2016 Aug;30(8):1672-81. doi: 10.1038/leu.2016.69. Epub 2016 Apr 11.

PLoS One. 2016 Feb 17;11(2):e0148346. doi: 10.1371/journal.pone.0148346. eCollection 2016.

Next generation sequencing of acute myeloid leukemia: influencing prognosis.急性髓系白血病的下一代测序：对预后的影响

BMC Genomics. 2015;16 Suppl 1(Suppl 1):S5. doi: 10.1186/1471-2164-16-S1-S5. Epub 2015 Jan 15.

Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups.急性早幼粒细胞白血病与其他髓系白血病亚组存在协同突变。

Blood Cancer J. 2013 Sep 13;3(9):e147. doi: 10.1038/bcj.2013.46.

Are results of targeted gene sequencing ready to be used for clinical decision making for patients with acute myelogenous leukemia?针对急性髓细胞白血病患者的靶向基因测序结果是否已准备好用于临床决策？

Curr Hematol Malig Rep. 2013 Jun;8(2):149-55. doi: 10.1007/s11899-013-0161-6.

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Somatic mutations in acute promyelocytic leukemia (APL) identified by exome sequencing.

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