Zhang Jian, Gong Yanjun, Yu Ying
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai, China.
Front Pharmacol. 2010 Oct 14;1:116. doi: 10.3389/fphar.2010.00116. eCollection 2010.
Prostaglandins (PGs), a group of key lipid mediators, are involved in numerous physiological and pathological processes including inflammation and cardiovascular homeostasis. Each PG acts on its specific and distinct cell surface G protein-coupled receptors (GPCRs) or peroxisome proliferator-activated receptors (PPARs). Prostaglandin F(2α) receptor (FP) is required for female reproductive function such as luteolysis and parturition. It has recently been implicated in blood pressure regulation, atherosclerosis and other inflammation-related disorders. The emerging role of FP in cardiovascular diseases is highlighted and potential therapeutic translation is discussed in the current review.
前列腺素（PGs）是一类关键的脂质介质，参与包括炎症和心血管稳态在内的众多生理和病理过程。每种PG作用于其特定且不同的细胞表面G蛋白偶联受体（GPCRs）或过氧化物酶体增殖物激活受体（PPARs）。前列腺素F（2α）受体（FP）是女性生殖功能如黄体溶解和分娩所必需的。最近它被认为与血压调节、动脉粥样硬化及其他炎症相关疾病有关。本综述强调了FP在心血管疾病中的新作用，并讨论了潜在的治疗转化。
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