Liu Min, Du Xifeng, Chen Huifang, Bai Chenkai, Lan Lizhen
Department of General Practice, First Hospital of Shanxi Medical University, No.85, Jiefang South Road, Taiyuan, Shanxi, 030001, China.
Regen Ther. 2024 Apr 11;27:290-300. doi: 10.1016/j.reth.2024.03.024. eCollection 2024 Dec.
Phthalate esters (PE), a significant class of organic compounds used in industry, can contaminate humans and animals by entering water and food chains. Recent studies demonstrate the influence of PE on the development and progression of heart diseases, particularly in obese people. Di-isobutyl phthalate (DIBP) was administered orally to normal and diet-induced obese mice in this research to assess cardiovascular risk. The modifications in the microbial composition and metabolites were examined using RNA sequencing and mass spectrometry analysis. Based on the findings, lean group rodents were less susceptible to DIBP exposure than fat mice because of their cardiovascular systems. Histopathology examinations of mice fed a high-fat diet revealed lesions and plagues that suggested a cardiovascular risk. In the chronic DIBP microbial remodeling metagenomics was the predominant genera in obese mice. According to metabolomics data, arachidonic acid (AA) metabolism changes caused by DIBP were linked to unfavorable cardiovascular events. Our research offers new understandings of the cardiovascular damage caused by DIBP exposure in obese people and raises the possibility that arachidonic acid metabolism could be used as a regulator of the gut microbiota to avert related diseases.
邻苯二甲酸酯（PE）是工业中使用的一类重要有机化合物，可通过进入水和食物链污染人类和动物。最近的研究表明PE对心脏病的发展和进程有影响，尤其是对肥胖人群。本研究通过对正常小鼠和饮食诱导的肥胖小鼠口服邻苯二甲酸二异丁酯（DIBP）来评估心血管风险。使用RNA测序和质谱分析检查微生物组成和代谢物的变化。基于这些发现，瘦组啮齿动物由于其心血管系统，比肥胖小鼠对DIBP暴露的敏感性更低。对高脂饮食喂养的小鼠进行组织病理学检查发现了病变和斑块，提示存在心血管风险。在慢性DIBP微生物重塑中，宏基因组学是肥胖小鼠中的主要属。根据代谢组学数据，DIBP引起的花生四烯酸（AA）代谢变化与不良心血管事件有关。我们的研究为肥胖人群中DIBP暴露导致的心血管损伤提供了新的认识，并提出花生四烯酸代谢可作为肠道微生物群的调节剂来预防相关疾病的可能性。
