Department of Surgery, Institut Claudius Regaud, Toulouse, France.
J Gynecol Oncol. 2011 Mar 31;22(1):9-17. doi: 10.3802/jgo.2011.22.1.9.
Early stage primary carcinoma of the fallopian tube (PCFT) is an uncommon condition when strict criteria are applied. The aim of this study was to compare the outcome stage IA-IB PCFT to a matched group of ovarian cancer (OC).
Between 1990 and 2008, 32 patients with stage IA-IB of PCFT were recorded in the database of three French Institutions. A control group of patients with OC was constituted.
Eleven eligible PCFT cases and 29 OC controls fulfilled the stringent inclusion criteria. Median follow-up was 70.2 months. Five-year overall survival was 83.3% (95% confidence interval [CI], 27.3 to 97.5) for PCFT and 88.0% (95% CI, 66.9 to 96.0) for OC (p=0.93). In the subgroup of patients with grade 2-3, the outcome was similar in PCFT compared to OC patients (p=0.75). Five-year relapse-free survival was respectively 62.5% (95% CI, 22.9 to 86.1) and 85.0% (95% CI, 64.6 to 94.2) in the PCFT and OC groups (p=0.07). In the subgroup of patients (grade 2-3), there was no difference between PCFT and OC (p=0.65).
The findings did not reveal any difference in prognosis between early stage of PCFT and OC when grade is taken into account. Management of PCFT should mirror that of ovarian carcinoma.
当采用严格的标准时，原发性输卵管癌（PCFT）的早期阶段是一种罕见的情况。本研究的目的是比较 IA-IB 期 PCFT 与卵巢癌（OC）的匹配组的结果。
1990 年至 2008 年期间，在法国三个机构的数据库中记录了 32 例 IA-IB 期 PCFT 患者。组成了 OC 患者的对照组。
11 例符合严格纳入标准的 PCFT 病例和 29 例 OC 对照组符合条件。中位随访时间为 70.2 个月。PCFT 的 5 年总生存率为 83.3%（95%置信区间 [CI]，27.3 至 97.5），OC 为 88.0%（95% CI，66.9 至 96.0）（p=0.93）。在 2-3 级患者亚组中，PCFT 的结果与 OC 患者相似（p=0.75）。PCFT 和 OC 组的 5 年无复发生存率分别为 62.5%（95% CI，22.9 至 86.1）和 85.0%（95% CI，64.6 至 94.2）（p=0.07）。在 2-3 级患者亚组中，PCFT 和 OC 之间没有差异（p=0.65）。
考虑到分级，PCFT 的早期阶段与 OC 的预后没有差异。PCFT 的管理应与卵巢癌的管理相类似。
