胰腺分泌性胰蛋白酶抑制剂：不止是一种胰蛋白酶抑制剂。
Pancreatic secretory trypsin inhibitor: More than a trypsin inhibitor.
作者信息
Wang Gai-Ping, Xu Cun-Shuan
机构信息
Gai-Ping Wang, Cun-Shuan Xu, College of Life Science, Henan Normal University, Xinxiang 453007, Henan Province, China.
出版信息
World J Gastrointest Pathophysiol. 2010 Jun 15;1(2):85-90. doi: 10.4291/wjgp.v1.i2.85.
Abstract
Kazal-type serine protease inhibitor is one of the most important and widely distributed protease inhibitor families. Pancreatic secretory trypsin inhibitor (PSTI), also known as serine protease inhibitor Kazal type I(SPINK1), binds rapidly to trypsin, inhibits its activity and is likely to protect the pancreas from prematurely activated trypsinogen. Therefore, it is an important factor in the onset of pancreatitis. Recent studies found that PSTI/SPINK1 is also involved in self-regulation of acinar cell phagocytosis, proliferation and growth of a variety of cell lines. In addition, it takes part in the response to inflammatory factor or injury and is highly related to adult type II citrullinemia.
摘要
卡扎尔型丝氨酸蛋白酶抑制剂是最重要且分布最广泛的蛋白酶抑制剂家族之一。胰腺分泌性胰蛋白酶抑制剂（PSTI），也称为丝氨酸蛋白酶抑制剂卡扎尔I型（SPINK1），能迅速与胰蛋白酶结合，抑制其活性，并可能保护胰腺免受过早激活的胰蛋白酶原的损伤。因此，它是胰腺炎发病的一个重要因素。最近的研究发现，PSTI/SPINK1还参与腺泡细胞吞噬作用的自我调节、多种细胞系的增殖和生长。此外，它参与对炎症因子或损伤的反应，与成人II型瓜氨酸血症高度相关。
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