Dellarovere F, Broccio G, Granata A, Fimiani V
UNIV MESSINA,SCH MED,INST GEN PATHOL,I-98122 MESSINA,ITALY. UNIV MESSINA,SCH MED,CHAIR EMERGENCY MED,I-98122 MESSINA,ITALY.
Oncol Rep. 1994 Jan;1(1):175-7.
Induction of hyperhistaminism in peritoneum of rats by daily intraperitoneal supply of 0.005 mu g of histamine, counteracts the growth of 10(3) Yoshida ascite sarcoma cells only if administration precedes inoculation of tumor cells and has a long duration. Treating animals for two weeks before tumor cell inoculation we observed significant 70% survival, that was increased to 80% continuing the supply for 20-days after the inoculation; treatment for 3 days before or 20 days after the inoculation did not show significant results. The condition created in rat peritoneum is similar to that in allergic people, and our data in animals confirm statistical data observed in allergic people showing decreased incidence of neoplastic disease due to histamine, that appears to be integrated in a highly potent immunoregulatory circuit.
通过每日腹腔注射0.005微克组胺在大鼠腹膜中诱导高组胺血症，只有在给药先于肿瘤细胞接种且持续时间长时，才能抵消10³个吉田腹水肉瘤细胞的生长。在肿瘤细胞接种前对动物进行两周治疗，我们观察到显著的70%存活率，在接种后继续给药20天，存活率提高到80%；在接种前3天或接种后20天进行治疗未显示出显著效果。大鼠腹膜中产生的状况与过敏人群相似，我们在动物身上的数据证实了在过敏人群中观察到的统计数据，即由于组胺导致肿瘤疾病发病率降低，这似乎整合到了一个高效的免疫调节回路中。
