Stranahan P, Laroe J, Reddy D, Rahim I, Overland M, Pettijohn D
UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM BIOPHYS & GENET,DENVER,CO 80262. UNIV COLORADO,CTR CANC,DENVER,CO 80262. UNIV COLORADO,DEPT MOLEC CELLULAR & DEV BIOL,BOULDER,CO 80304.
Oncol Rep. 1994 May;1(3):607-11. doi: 10.3892/or.1.3.607.
The extended Le(a)-Le(x) oligosaccharide, expressed as a cell surface antigen by human squamous lung carcinomas marks cancer cells of tumors having poor prognosis. In order to see if the extended Le(a)-Le(x) also has a precisely controlled pattern of expression during embryogenesis, a survey of representative vertebrate embryos and fetuses in various stages was undertaken. Embryonic and fetal cells which express the epitope are derived from embryonic endoderm. No. epitope expression was demonstrated in tissues of ectodermal or mesodermal origin. Vertebrate conservation of this endodermal cell surface carbohydrate suggests function necessary for normal growth and development with inappropriate re-expression during carcinogenesis.
人肺鳞状细胞癌作为细胞表面抗原表达的延伸Le(a)-Le(x)寡糖标记预后不良肿瘤的癌细胞。为了探究延伸Le(a)-Le(x)在胚胎发育过程中是否也有精确调控的表达模式，我们对处于不同阶段的代表性脊椎动物胚胎和胎儿进行了调查。表达该表位的胚胎和胎儿细胞来源于胚胎内胚层。在外胚层或中胚层来源的组织中未证实有表位表达。这种内胚层细胞表面碳水化合物在脊椎动物中的保守性表明其对正常生长和发育是必需的，而在致癌过程中会不适当重新表达。
