Alhan E
Department of Surgery, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Z Gastroenterol. 1990 Mar;28(3):139-41.
In this study, the effect of naloxone in the prevention of experimental stress ulcers was investigated. A prophylactic effect of naloxone on stress ulcer formation was not observed. On the contrary, naloxone increased the gastric lesion score. Naloxone did neither decrease gastric acidity in stress nor in non-stress conditions. Under non-stress conditions naloxone did not change gastric mucosal barrier by reducing Na+ and K+ ion concentrations of the gastric secretion. Under stress conditions the barrier could not be maintained. Naloxone decreased gastric mucus production under stress.
在本研究中，对纳洛酮预防实验性应激性溃疡的效果进行了调查。未观察到纳洛酮对应激性溃疡形成有预防作用。相反，纳洛酮增加了胃损伤评分。纳洛酮在应激和非应激条件下均未降低胃酸分泌。在非应激条件下，纳洛酮未通过降低胃分泌液中的Na+和K+离子浓度来改变胃黏膜屏障。在应激条件下，该屏障无法维持。纳洛酮在应激状态下减少了胃黏液分泌。
