Abalakin V A, Sirina E G, Cherkasova T D
Zh Mikrobiol Epidemiol Immunobiol. 1990 Feb(2):62-7.
The mixture of purified protective antigen (PA) and the lethal factor (LF) of B. anthracis exotoxin in a dose incapable of causing cell damage inhibited the zymosan-stimulated luminol-dependent chemiluminescence of mononuclear phagocytes (MP) and polymorphonuclear neutrophils (PMN) in CBA mice and enhanced the chemiluminescence of PMN in BALB/c, CC57W and A/Sn mice. The conclusion is made that the capacity of mixture of PA and LF for the in vitro inhibition of stimulated production of active forms of oxygen in MP and PMN is directly related to the in vivo immunosuppressing activity of B. anthracis toxin. But the influence of the mixture of PA and LF on the production of active forms of oxygen in MP and PMN is not the leading factor of natural immunity to B. anthracis infection in mice.
纯化的炭疽芽孢杆菌外毒素保护性抗原（PA）和致死因子（LF）的混合物，在剂量不足以引起细胞损伤时，可抑制CBA小鼠单核吞噬细胞（MP）和多形核中性粒细胞（PMN）受酵母聚糖刺激的鲁米诺依赖性化学发光，并增强BALB/c、CC57W和A/Sn小鼠PMN的化学发光。得出的结论是，PA和LF混合物体外抑制MP和PMN中活性氧形式刺激产生的能力与炭疽芽孢杆菌毒素的体内免疫抑制活性直接相关。但PA和LF混合物对MP和PMN中活性氧形式产生的影响并非小鼠对炭疽芽孢杆菌感染天然免疫的主要因素。
