Hidalgo, I. J., Raub, T. J., and Borchardt, R. T.: Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability, Gastroenterology, 96, 736-749, 1989--the backstory.
作者信息
Borchardt Ronald T
机构信息
Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, 66047, USA.
出版信息
AAPS J. 2011 Sep;13(3):323-7. doi: 10.1208/s12248-011-9283-8. Epub 2011 May 24.
Abstract
摘要
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Hidalgo, I. J., Raub, T. J., and Borchardt, R. T.: Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability, Gastroenterology, 96, 736-749, 1989--the backstory.伊达尔戈，I. J.，劳布，T. J.，和博查德特，R. T.：将人结肠癌细胞系（Caco-2）表征为肠道上皮通透性的模型系统，《胃肠病学》，96，736 - 749，1989——背景故事
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本文引用的文献
1
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Pharm Res. 1986 Apr;3(2):81-7. doi: 10.1023/A:1016337202335.
2
In Vitro Drug Absorption Models. II. Salicylate, Cefoxitin, α-Methyldopa and Theophylline Uptake in Cells and Rings: Correlation with In Vivo Bioavailability.在体药物吸收模型。二、柳酸盐、头孢西丁、α-甲基多巴和茶碱在细胞和环中的摄取：与体内生物利用度的相关性。
Pharm Res. 1985 Nov;2(6):293-8. doi: 10.1023/A:1016393618111.
3
In vitro drug absorption models. I. Brush border membrane vesicles, isolated mucosal cells and everted intestinal rings: characterization and salicylate accumulation.体外药物吸收模型。I. 刷状缘膜囊泡、分离的黏膜细胞和外翻肠环：特征描述和水杨酸积聚。
Pharm Res. 1985 Nov;2(6):284-93. doi: 10.1023/A:1016341601273.
4
Intestinal absorption of alpha-methyldopa: in vitro mechanistic studies in rat small intestinal segments.α-甲基多巴的肠道吸收：大鼠小肠段的体外机制研究
J Pharmacol Exp Ther. 1987 Aug;242(2):443-9.
5
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability.将人结肠癌细胞系（Caco-2）作为肠道上皮通透性模型系统的特性研究
Gastroenterology. 1989 Mar;96(3):736-49.
6
Binding of epidermal growth factor by human colon carcinoma cell (Caco-2) monolayers.人结肠癌细胞（Caco-2）单层对表皮生长因子的结合
Biochem Biophys Res Commun. 1989 Apr 14;160(1):317-24. doi: 10.1016/0006-291x(89)91658-6.
7
Transport of bile acids in a human intestinal epithelial cell line, Caco-2.胆汁酸在人肠上皮细胞系Caco-2中的转运。
Biochim Biophys Acta. 1990 Jul 20;1035(1):97-103. doi: 10.1016/0304-4165(90)90179-z.
8
Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa.Caco-2细胞单层作为药物跨肠黏膜转运的模型。
Pharm Res. 1990 Sep;7(9):902-10. doi: 10.1023/a:1015937605100.
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Transport of a large neutral amino acid (phenylalanine) in a human intestinal epithelial cell line: Caco-2.一种大型中性氨基酸（苯丙氨酸）在人肠上皮细胞系Caco-2中的转运
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10
The use of cultured epithelial and endothelial cells for drug transport and metabolism studies.利用培养的上皮细胞和内皮细胞进行药物转运和代谢研究。
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