人体组织中D-氨基酸氧化酶的遗传和生化特性。
The genetic and biochemical properties of the D-amino acid oxidases in human tissues.
作者信息
Barker R F, Hopkinson D A
出版信息
Ann Hum Genet. 1977 Jul;41(1):27-42. doi: 10.1111/j.1469-1809.1977.tb01959.x.
Abstract
- Two distinct forms of oxidases catalysing the oxidative deamidation of D-alpha-amino acids have been identified in human tissues: D-amino acid oxidase (DAMOX) and D-aspartate oxidase (DASOX). 2. The enzymes differ in their electrophoretic properties, tissue distribution, binding with flavine adenine denucleotide, heat stability, molecular size and possibly in subunit structure. 3. Neither enzyme exhibits genetic polymorphism in European populations, but a rare electrophoretic variant phenotype (DASOX 2-1) was identified which suggests that the DASOX locus is autosomal and independent of the DAMOX locus.
摘要
- 在人体组织中已鉴定出两种催化D-α-氨基酸氧化脱酰胺作用的不同形式的氧化酶：D-氨基酸氧化酶（DAMOX）和D-天冬氨酸氧化酶（DASOX）。2. 这两种酶在电泳性质、组织分布、与黄素腺嘌呤二核苷酸的结合、热稳定性、分子大小以及可能的亚基结构方面存在差异。3. 在欧洲人群中，这两种酶均未表现出遗传多态性，但鉴定出一种罕见的电泳变异表型（DASOX 2-1），这表明DASOX基因座是常染色体的，且独立于DAMOX基因座。
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