Minh H N, Smadja A, Delteil C, Sevestre C
Service d'Anatomie Pathologique, Centre Hospitalier, Amiens.
Arch Anat Cytol Pathol. 1990;38(1-2):11-7.
We report a case of pflügerome, a tumor now designated by the term "mixed germ cell sex cord and stroma tumor". This infrequent tumor consists in a proliferation of germ cells surrounded by Sertoli-granulosa-type cells and arises in patients with a feminine phenotype and a 46XY karyotype; it should be differentiated from gonadoblastomas that are seen in patients with a female phenotype and a 46XY or 46XX/46XY mosaic karyotype. Prognosis is good and recovery occurs following exeresis. On the basis of their studies on gonadal differentiation in human embryos, the authors propose the following terms: "tumors of the gonadal anlage with male differenciation" for gonadoblastomas, "tumors of the gonadal anlage with female differentiation" for pflügeromes.
我们报告了一例普弗勒格瘤（pflügerome），这是一种现被称为“混合性生殖细胞性索间质肿瘤”的肿瘤。这种罕见肿瘤由被支持-颗粒细胞型细胞包围的生殖细胞增殖构成，发生于具有女性表型和46XY核型的患者；它应与见于具有女性表型和46XY或46XX/46XY嵌合核型患者的性腺母细胞瘤相鉴别。预后良好，切除术后可恢复。基于他们对人类胚胎性腺分化的研究，作者提出以下术语：性腺母细胞瘤为“具有男性分化的性腺原基肿瘤”，普弗勒格瘤为“具有女性分化的性腺原基肿瘤”。
