Thompson D L, Horton N, Rittmaster R S
Department of Medicine, Dalhousie University, Halifax, Nova Scotia.
Clin Endocrinol (Oxf). 1990 Mar;32(3):283-92. doi: 10.1111/j.1365-2265.1990.tb00868.x.
Androsterone glucuronide (Andros-G), a dihydrotestosterone metabolite, is present in serum at concentrations at least tenfold greater than those of androstanediol glucuronide. To investigate the significance of serum androsterone glucuronide, we developed a direct radioimmunoassay for this compound and measured its levels in normal women, women with mild or severe idiopathic hirsutism (IH), hirsute women with polycystic ovarian syndrome (PCO), and non-hirsute obese women. To determine the source of Andros-G precursors, serum levels were measured before and after selective ovarian suppression with leuprolide, combined ovarian and adrenal suppression with leuprolide and dexamethasone, and adrenal stimulation with ACTH. Androsterone glucuronide levels (nmol/l; mean +/- SD) were significantly higher (P less than 0.025) in women with mild idiopathic hirsutism (IH) (185 +/- 91), severe IH (173 +/- 97), and hirsute women with polycystic ovarian syndrome (PCO) (178 +/- 102) than in normal women (110 +/- 26). Levels in non-hirsute obese women (64 +/- 19) were lower than in normal women (P less than 0.01). Baseline levels (mean +/- SEM) in hirsute women given 20 micrograms/kg/day leuprolide for 5-9 months (171 +/- 15) were not significantly changed after leuprolide alone (153 +/- 18), and were decreased after adding dexamethasone (19 +/- 6; P less than 0.001). Andros-G levels did not increase significantly in normal women 60 min after i.v. ACTH (112 +/- 14 to 126 +/- 19), but rose in IH (170 +/- 24 to 216 +/- 26; P less than 0.001) and in PCO (179 +/- 26 to 238 +/- 31; P = 0.002). We conclude that Andros-G in women arises primarily from adrenal gland precursors and is elevated in hirsute women as a group. Its levels do not correlate with the severity of hirsutism, or the presence or absence of PCO, but reflect an increased production of adrenal androgens in both IH and PCO.
雄酮葡糖苷酸（Andros - G）是二氢睾酮的一种代谢产物，其在血清中的浓度至少比雄烷二醇葡糖苷酸高10倍。为了研究血清雄酮葡糖苷酸的意义，我们开发了一种针对该化合物的直接放射免疫测定法，并测量了正常女性、轻度或重度特发性多毛症（IH）女性、患有多囊卵巢综合征（PCO）的多毛女性以及非多毛肥胖女性体内的该物质水平。为了确定Andros - G前体的来源，我们在使用亮丙瑞林进行选择性卵巢抑制、使用亮丙瑞林和地塞米松联合进行卵巢和肾上腺抑制以及使用促肾上腺皮质激素（ACTH）进行肾上腺刺激前后，测量了血清水平。轻度特发性多毛症（IH）女性（185±91）、重度IH女性（173±97）以及患有多囊卵巢综合征（PCO）的多毛女性（178±102）体内的雄酮葡糖苷酸水平（nmol/l；均值±标准差）显著高于正常女性（110±26）（P＜0.025）。非多毛肥胖女性的水平（64±19）低于正常女性（P＜0.01）。接受20微克/千克/天亮丙瑞林治疗5至9个月的多毛女性的基线水平（均值±标准误）（171±15），在单独使用亮丙瑞林后（153±18）无显著变化，而在添加地塞米松后降低（19±6；P＜0.001）。静脉注射ACTH 60分钟后，正常女性的Andros - G水平未显著升高（从112±14升至126±19），但在IH女性中升高（从170±24升至216±26；P＜0.001），在PCO女性中也升高（从179±26升至238±31；P = 0.002）。我们得出结论，女性体内的Andros - G主要来源于肾上腺前体，并且作为一个群体，其在多毛女性中升高。其水平与多毛症的严重程度、PCO的有无无关，但反映了IH和PCO中肾上腺雄激素产生的增加。
