Laher M S
James Connolly Hospital, Dublin, Ireland.
Drugs. 1990;39 Suppl 2:55-63. doi: 10.2165/00003495-199000392-00011.
The efficacy and tolerability of lisinopril administered once daily were evaluated in a 12-week open study of 60 elderly patients aged between 65 and 85 years (mean 75 years) with essential hypertension. Mean sitting blood pressure was reduced from 190/106 +/- 6.3/1.3mm Hg (mean +/- SEM) at entry to 162/89 +/- 5.5/0.9 mm Hg after 12 weeks of treatment (p less than 0.001). There was no significant alteration in heart rate, and no occurrence of postural hypotension. The median daily dose of lisinopril was 20mg (range 5 to 40 mg) and only 4 patients required the addition of a diuretic. Mean glomerular filtration rate (GFR) at entry was 61.6 +/- 3.4 ml/min and was unchanged after 12 weeks of therapy. 25 patients continued to receive treatment for 1 year, and 20 of these completed 2 years of treatment. Control of blood pressure was maintained, and heart rate, biochemical parameters and GFR remained unaltered throughout the study. Renal function was preserved and renal blood flow, measured in a group of 14 patients, was significantly increased (p less than 0.025) at the end of the first year after treatment with lisinopril. Thus, in the elderly, lisinopril was well tolerated and highly effective in lowering blood pressure, and renal function was maintained.
在一项针对60名年龄在65至85岁（平均75岁）的老年原发性高血压患者的12周开放性研究中，评估了每日服用一次赖诺普利的疗效和耐受性。治疗前平均坐位血压为190/106±6.3/1.3mmHg（平均值±标准误），治疗12周后降至162/89±5.5/0.9mmHg（p<0.001）。心率无显著变化，未发生体位性低血压。赖诺普利的每日中位剂量为20mg（范围5至40mg），只有4名患者需要加用利尿剂。治疗前平均肾小球滤过率（GFR）为61.6±3.4ml/min，治疗12周后无变化。25名患者继续接受治疗1年，其中20名完成了2年治疗。在整个研究过程中，血压控制得以维持，心率、生化参数和GFR均无改变。肾功能得以保留，在一组14名患者中测量的肾血流量在赖诺普利治疗第一年末显著增加（p<0.025）。因此，对于老年人，赖诺普利耐受性良好，降压效果显著，且肾功能得以维持。
