Nørgaard A, Jensen J H, Andreasen F
Department of Cardiology, Aarhus University Hospital, Denmark.
Eur J Clin Pharmacol. 1990;38(4):397-9. doi: 10.1007/BF00315584.
Na,K-ATPase, or the Na,K-pump, is essential for the excitability and contractility of muscle tissue. Hypothyroidism in associated with a marked decrease in the Na,K-pump concentration in skeletal muscle and myocardium. In 7 patients on long-term amiodarone treatment there was a 36% reduction in the concentration of 3H-ouabain binding sites in skeletal muscle biopsies compared to 7 healthy subjects. This decrease during long-term amiodarone treatment may represent an equivalent reduction in the concentration of the functional Na,K-pump and it may be important in the adverse effect of amiodarone on muscle.
钠钾-ATP酶，即钠钾泵，对于肌肉组织的兴奋性和收缩性至关重要。甲状腺功能减退与骨骼肌和心肌中钠钾泵浓度显著降低有关。与7名健康受试者相比，7名接受长期胺碘酮治疗的患者骨骼肌活检中3H-哇巴因结合位点浓度降低了36%。长期胺碘酮治疗期间的这种降低可能代表功能性钠钾泵浓度同等程度的降低，这可能在胺碘酮对肌肉的不良反应中起重要作用。
