[Correlation of endogenous androgen and androgen receptor level with coronary artery diseases in elderly males].

OBJECTIVE

To investigate the correlation of endogenous androgen and androgen receptor (AR) level with coronary artery diseases (CAD) in elderly males and elucidate the potential mechanism of gender difference in the prevalence of CAD.

METHODS

A total of 296 male patients from different centers were divided into the CAD group (n = 237) and the control group (n = 59) according to the results of coronary angiography. Their mean ages were 68.6 ± 6.8 and 66.2 ± 6.5 years old respectively. The serum levels of FT (free testosterone), TT (total testosterone), E2 (estradiol), LH (luteinizing hormone), FSH (follicle-stimulating hormone), SHBG (sex hormone-binding globulin) and DHEA (dehydroepiandrosterone) were measured in all participants. And the androgen receptors of peripheral lymphocytes were assessed by flow cytometry.

RESULTS

The serum level of FT was lower in the CAD group than that in the control group [(24.1 ± 22.2) × 10(-9) mmol/L vs (34.1 ± 31.8) × 10(-9) mmol/L, P = 0.06]. But two groups showed no statistic differences in the levels of TT, E(2), LH, FSH, SHBG, DHEA and lymphocyte AR (56.3% ± 24.00 vs 57.1% ± 20.8%). As demonstrated by the logistic regression analysis, the level of FT was negatively correlated with the CAD risk (OR = 0.98, P = 0.0049) and positively correlated with the peripheral lymphocyte AR level. However age was negatively correlated with the levels of FT and AR.

CONCLUSION

The deficiency of endogenous androgen contributes to a high prevalence of CAD in elderly males. The age-related decreases of FT and AR impair the physiological functions of androgen so as to accelerate the progression of coronary atherosclerosis.