Centre de Recherche de l'Hôpital Sainte-Justine, Département de Pharmacologie, Université de Montréal, Canada.
Exp Hematol. 2011 Aug;39(8):809-16. doi: 10.1016/j.exphem.2011.04.008. Epub 2011 May 10.
Interactions between hematopoiesis and bone metabolism have been described in various developmental and pathological situations. Here we review this evidence from the literature with a focus on microenvironmental regulation of hematopoiesis and bone metabolism. Our hypothesis is that this process occurs by bidirectional signaling between hematopoietic and mesenchymal cells through cell adhesion molecules, membrane-bound growth factors, and secreted matrix proteins. Examples of steady-state hematopoiesis and pathologies are presented and support our view that hematopoietic and mesenchymal cell functions are modulated by specific microenvironments in the bone marrow.
造血与骨代谢之间的相互作用在各种发育和病理情况下均有描述。本文通过文献复习对此进行综述，重点关注造血与骨代谢的微环境调控。我们的假说为，此过程通过造血细胞与间充质细胞间的双向信号转导实现，涉及细胞黏附分子、膜结合生长因子和分泌的基质蛋白。本文呈现了稳态造血和病理情况下的相关实例，支持我们的观点，即骨髓中特定的微环境可调节造血细胞与间充质细胞的功能。
