Stambolieva Katerina, Angov Georgi
Department of Cognitive Psychophysiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Int Tinnitus J. 2010;16(1):32-6.
The effect of betahistine dihydrochloride on the postural stability after repositioning Epley's maneuver (EM) in patients with BPPV was evaluated by static posturography in open and closed eyes conditions. Ninety patients were divided into four groups by duration (less and above 60 days of BPPV) and by treatment (with and without treatment with betahistine). The investigation was made one hour after the positive Dix-Hallpike test, 10 and 20 days after the treatment with EM. "Sway velocity" (SV) was calculated to evaluate postural stability. The results show dependence between efficacy of treatment with betahistine applied after EM and duration of BPPV. Betahistine normalized postural stability of patients with duration of BPPV less than 60 days after 10 days of treatment and had less effect on patients with duration of BPPV above 60 days. We assume that after removing the otoconia betahistine plays an important role for improving blood flow in the inner ear. The short presence of otoconia didn't damage sensory receptor, and restoring the normal function of motion-sensitive hairs cells and stabilizing the posture was observed.
通过在睁眼和闭眼条件下进行静态姿势描记法，评估了倍他司汀二盐酸盐对良性阵发性位置性眩晕（BPPV）患者进行Epley手法复位（EM）后姿势稳定性的影响。90名患者根据病程（BPPV病程小于60天和大于60天）和治疗情况（接受和未接受倍他司汀治疗）分为四组。在阳性Dix-Hallpike试验后1小时、EM治疗后10天和20天进行调查。计算“摆动速度”（SV）以评估姿势稳定性。结果显示，EM后应用倍他司汀治疗的疗效与BPPV病程之间存在相关性。倍他司汀治疗10天后可使BPPV病程小于60天的患者姿势稳定性恢复正常，而对BPPV病程大于60天的患者影响较小。我们推测，去除耳石后，倍他司汀在改善内耳血流方面发挥重要作用。耳石短暂存在并未损害感觉感受器，观察到运动敏感毛细胞的正常功能得以恢复且姿势得以稳定。
