Gisselbrecht C, Marty M, Boiron M
Sem Hop. 1978;54(41-42):1261-4.
Dynamic studies of anti-neoplasic agents provide a mathematical expression of various biological steps. High specific technics of dosage make possible the measurements of the drugs and their metabolites. Pharmacokinetics provides a new approach to three fundamental aspects in oncology: drug toxicity, relationship between drug schedule and response in each individual, drug resistance to anticancer drugs. Rational therapeutic approaches are made possible, as it was shown by the use of high dose of methotrexate.
抗肿瘤药物的动态研究提供了各种生物学步骤的数学表达式。高特异性的给药技术使药物及其代谢产物的测量成为可能。药代动力学为肿瘤学的三个基本方面提供了一种新方法：药物毒性、每个个体中给药方案与反应之间的关系、抗癌药物的耐药性。合理的治疗方法成为可能，高剂量甲氨蝶呤的使用就证明了这一点。
