Diyarbakır Training and Research Hospital, Turkey.
Seizure. 2011 Oct;20(8):598-601. doi: 10.1016/j.seizure.2011.04.014. Epub 2011 May 25.
It is accepted that the estradiol hormone is proconvulsant and progesterone is anti-convulsant. In this study the effects of gonadal hormones on photoparoxysmal responses on EEG in idiopathic generalised epilepsy were researched.
Twenty-two women with photosensitive idiopathic generalised epilepsy having regular menstrual cycles were recruited into the study. Patients presenting photoparoxysmal responses were selected from routine EEG recordings. Blood samples were taken on day 14 (E) and 25 (P) of the menstrual cycle to confirm E and P peaks. An EEG recording was performed for each patient on E and P days.
No statistically significant differences were monitored with respect to frequency, duration of the photoparoxysmal responses on E and P peaks days (p>0.05).
In this study no correlation could be demonstrated among menstrual cycle and photoparoxysmal responses.
雌激素具有促惊厥作用，孕激素具有抗惊厥作用，这一点已被广泛接受。本研究旨在探讨性腺激素对特发性全面性癫痫患者脑电图光激反应的影响。
研究纳入了 22 名具有光敏感性特发性全面性癫痫且月经周期规律的女性患者。从常规脑电图记录中选择具有光激反应的患者。在月经周期的第 14 天（E）和第 25 天（P）采血以确认 E 和 P 峰值。为每位患者在 E 天和 P 天进行脑电图记录。
在 E 天和 P 天的光激反应频率和持续时间方面，未监测到统计学显著差异（p>0.05）。
本研究未能证明月经周期与光激反应之间存在相关性。
