Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt.
Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1331-7. doi: 10.1016/j.saa.2011.04.064. Epub 2011 May 5.
N-(thiophen-2-ylmethylene)benzo[d]thiazol-2-amine Schiff base (L) derived from 2-aminobenzothiazole and 2-thiophenecarboxaldehyde was synthesized and characterized using elemental analysis, IR, mass spectra, (1)H NMR and UV-vis spectra. Its complexes with Cu(II), Fe(III), Ni(II) and Zn(II) were prepared and isolated as solid products and characterized by elemental and thermal analyses, spectral techniques as well as magnetic susceptibility. The IR spectra showed that the Schiff base under investigation behaves as bidentate ligand. The UV-vis spectra and magnetic moment data suggested octahedral geometry around Cu(II) and Fe(III) and tetrahedral geometry around Ni(II) and Zn(II). In view of the biological activity of the Schiff base and its complexes, it has been observed that the antimicrobial activity of the Schiff base increased on complexation with the metal ion. In vitro antitumor activity assayed against five human tumor cell lines furnished the significant toxicities of the Schiff base and its complexes.
N-(噻吩-2-亚甲基)苯并[d]噻唑-2-胺席夫碱（L）由 2-氨基苯并噻唑和 2-噻吩甲醛合成，并通过元素分析、IR、质谱、（1）H NMR 和 UV-vis 光谱进行了表征。它与 Cu(II)、Fe(III)、Ni(II)和 Zn(II)的配合物作为固体产物制备并分离，并通过元素和热分析、光谱技术以及磁化率进行了表征。IR 光谱表明，所研究的席夫碱作为双齿配体。UV-vis 光谱和磁矩数据表明，Cu(II)和 Fe(III)周围的几何形状为八面体，Ni(II)和 Zn(II)周围的几何形状为四面体。鉴于席夫碱及其配合物的生物活性，已经观察到席夫碱与金属离子配位后抗菌活性增加。对五种人肿瘤细胞系进行的体外抗肿瘤活性测定表明，席夫碱及其配合物具有显著的毒性。
