Ciatto S, Grazzini G, Iossa A, Del Turco M R, Bravetti P, Cataliotti L, Cardona G, Bianchi S
Centro per lo Studio e la Prevenzione Oncologica, Firenze, Italy.
Eur J Surg Oncol. 1990 Jun;16(3):220-4.
We report on 156 consecutive cases of in situ ductal carcinoma (DCIS) of the breast observed from 1968 to 1988. The relative frequency of DCIS was much higher in screened, with respect to self-referred, women and a significant association of DCIS with younger age was observed. The combined use of mammography and physical examination identified 138 of 156 total DCIS cases as suspicious. Mammography, physical examination or cytology (of nipple discharge or needle aspirate) were the only tests to provide suspicious evidence in 35, 22 and four cases respectively. DCIS was a relatively unexpected surgical finding in 13 apparently benign cases. Different surgical options were recorded in the study period but a temporal trend in favour of conservative surgery was evident. Subsequent ipsilateral or contralateral breast cancer was recorded in seven and six cases respectively. Death from breast cancer occurred in five cases, all of whom had contralateral or subsequent ipsilateral infiltrating cancer. This figure confirms the high curability of DCIS if local control is achieved.
我们报告了1968年至1988年期间观察到的156例连续性乳腺导管原位癌（DCIS）病例。与自行就诊的女性相比，筛查出的女性中DCIS的相对发生率要高得多，并且观察到DCIS与较年轻的年龄存在显著关联。乳腺钼靶检查和体格检查相结合，在156例DCIS病例中识别出138例可疑病例。乳腺钼靶检查、体格检查或细胞学检查（乳头溢液或针吸活检）分别在35例、22例和4例病例中提供了可疑证据。在13例明显为良性的病例中，DCIS是相对意外的手术发现。在研究期间记录了不同的手术选择，但明显存在倾向于保守手术的时间趋势。分别有7例和6例随后发生同侧或对侧乳腺癌。5例死于乳腺癌，所有这些病例均患有对侧或随后发生的同侧浸润性癌。这一数字证实了如果实现局部控制，DCIS具有很高的治愈率。
