[结构与喷苯酮相近的物质在大鼠和小鼠中的降血脂活性]
[Hypolipidemic activity of substances structurally close to penphenone in rats and mice].
作者信息
Polikarpova L I, Reznik S E, Ryzhenkov V V, Khechinashvili G G, Petrova L A
出版信息
Vopr Med Khim. 1978 Nov-Dec;24(6):835-9.
Effect of substances, structurally related to penphenone (2-phenyl-3-methyl-3-hydroxypentanic acid sodium salt), was studied on the main patterns of lipid metabolism in blood of rats and mice, as well as on lipoprotein spectra of rat blood serum. All the compounds studied exhibited hypolipidemic effect, decreasing concentration of total cholesterol, cholesterol of alpha-lipoproteins and triglycerides in rat blood. The effect was less distinct in mice. 2-phenyl-3,4-dimethyl-3-hydroxypentanic acid sodium salt possessed the most pronounced hypolipidemic effect. A decrease in content of beta-and pre-beta-lipoproteins as well as of alpha-lipoproteins was observed after electrophoretic separation of blood serum lipoproteins in polyacrylamide gel in animals treated with the compound.
研究了与喷苯酮（2-苯基-3-甲基-3-羟基戊酸钠盐）结构相关的物质对大鼠和小鼠血液中脂质代谢主要模式以及大鼠血清脂蛋白谱的影响。所有研究的化合物均表现出降血脂作用，可降低大鼠血液中总胆固醇、α-脂蛋白胆固醇和甘油三酯的浓度。该作用在小鼠中不太明显。2-苯基-3,4-二甲基-3-羟基戊酸钠盐具有最显著的降血脂作用。在用该化合物处理的动物中，通过聚丙烯酰胺凝胶电泳分离血清脂蛋白后，观察到β-脂蛋白、前β-脂蛋白以及α-脂蛋白含量均有所降低。
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