Postgraduate Program in Pharmacology, Health Science Centre, Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil.
Cell Biochem Biophys. 2011 Nov;61(2):297-302. doi: 10.1007/s12013-011-9212-6.
Immune response and inflammation were suggested to play certain roles in the development and complications of type 2 diabetes mellitus. The main objective of this study was to investigate the CD26 expression and its relationship with adenosine deaminase (ADA), dipeptidyl peptidase IV (DPP-IV), γ-glutamyltransferase (GGT), and N-acetyl-β-glucosaminidase (NAG) activities in lymphocytes of type 2 diabetics (T2DM) patients. These parameters were assessed in 25 T2DM patients and 20 control subjects. We observed a decrease in CD26 expression and a significant increase in the ADA activity in T2DM patients when compared with control subjects. There were no differences between activities of DPP-IV, NAG, and GGT in lymphocytes of T2DM patients and control subjects. Meanwhile, a significant negative correlation was observed between CD26 expression and DPP-IV activity in lymphocytes of T2DM patients. Moreover, a positive correlation was found between DPPIV and ADA activities. The results suggest that the reduction of CD26 expression may be associated in the regulation of DPP-IV in T2DM patients.
免疫反应和炎症被认为在 2 型糖尿病的发生和并发症中起一定作用。本研究的主要目的是研究 2 型糖尿病（T2DM）患者淋巴细胞中 CD26 表达及其与腺苷脱氨酶（ADA）、二肽基肽酶 IV（DPP-IV）、γ-谷氨酰转移酶（GGT）和 N-乙酰-β-氨基葡萄糖苷酶（NAG）活性的关系。我们观察到 25 例 T2DM 患者与 20 例对照组相比，CD26 表达降低，ADA 活性显著升高。T2DM 患者和对照组淋巴细胞中 DPP-IV、NAG 和 GGT 的活性无差异。同时，我们还观察到 T2DM 患者淋巴细胞中 CD26 表达与 DPP-IV 活性呈显著负相关。此外，还发现 DPPIV 与 ADA 活性之间存在正相关。结果表明，CD26 表达的降低可能与 T2DM 患者 DPP-IV 的调节有关。
