Dvorakovskaia I V
Vopr Onkol. 1978;24(12):28-34.
Changes in the lung tissue in bronchial adenomas are not dependent on their histological structure, but on the anatomical form of growth, localization and duration of the existance. Both peripheral adenomas and cancer may have an asymptomatic course. In central (especially exophitic) adenomas distelectasis, atelectasis, fibrosis and vascular regeneration develop in sequence, while with the secondary infection-pneumonic foci. In relation to the mechanism of the development, lung tissue changes may arise as a result of invasive tumor growth, hypoxia, and impaired drainage function of the bronchi, toxico-immunological disturbances.
支气管腺瘤肺组织的改变不取决于其组织结构，而是取决于生长的解剖形式、部位及存在时间。周围型腺瘤和癌都可能呈无症状病程。中央型（尤其是外突型）腺瘤会依次出现肺膨胀不全、肺不张、纤维化和血管再生，继发感染时则会出现肺炎病灶。就发病机制而言，肺组织的改变可能是由于肿瘤浸润性生长、缺氧、支气管引流功能受损以及毒理免疫紊乱所致。
