Franzen D, Bürgi U, Gaspert A, Kohler M
Klinik für Pneumologie, Universitätsspital Zürich, Rämistrasse 100, 8091 Zürich.
Praxis (Bern 1994). 2011 May 25;100(11):659-63. doi: 10.1024/1661-8157/a000544.
In a patient with rheumatoid arthritis (RA) and asymptomatic, diffuse reticulo-nodular lung parenchymal alterations with upper lobe predominance, a Caplan syndrome (CS) was diagnosed. According to the size of the pulmonary nodules, classification into two subtypes of the CS has been proposed: the classic (Caplan) type and the silicotic type. Patients with CS often present with considerable x-ray or computertomographic changes but relatively few symptoms. However, in case of respiratory symptoms, infectious complications or pneumotoxic side effects of the immunsuppressive/immune-modulating pharmacotherapy for RA must be encountered in the differential diagnosis.
在一名患有类风湿性关节炎（RA）且无症状、肺部实质呈弥漫性网状结节改变且以上叶为主的患者中，诊断为卡普兰综合征（CS）。根据肺结节的大小，已提出将CS分为两种亚型：经典（卡普兰）型和矽肺型。CS患者的X线或计算机断层扫描通常有明显改变，但症状相对较少。然而，出现呼吸道症状时，鉴别诊断必须考虑RA免疫抑制/免疫调节药物治疗的感染性并发症或肺毒性副作用。
