Solomon S, Wise P M, Sanborn C, Ratner A
Yale J Biol Med. 1978 May-Jun;51(3):373-9.
In rats no consistent change in the concentration of cyclic GMP or cyclic AMP concentration was found in the renal cortex between 2 hours and seven days after unilateral nephrectomy. In regenerating liver tissue, between 2 hours and seven days after removal of one-third of the liver, there were no consistent changes in cyclic GMP concentrations, but cyclic AMP concentrations were higher than in controls. During postnatal growth, no consistent changes occurred in the cyclic GMP concentration of the spleen, the testes, the kidney cortex, the renal papilla, the liver or the ventricle between two and sixty days after birth. Cyclic AMP concentration on the other hand, in all these tissues with the exception of the spleen, was depressed between the twenty-first and fortieth day after birth, i.e., at a period of rapid growth. In the spleen, the concentration of cyclic AMP increased continuously from the second to the fifth day after birth. During renal parenchymal hyperplasia induced by a large intravenous dose of folic acid two days before sacrifice, the concentration of cyclic GMP in renal cortical tissue increased consistently. A model is proposed to explain the different patterns of changes in the cyclic nucleotide concentrations found.
在大鼠中，单侧肾切除术后2小时至7天，肾皮质中环状鸟苷酸（cGMP）或环状腺苷酸（cAMP）的浓度未发现一致的变化。在切除三分之一肝脏后的2小时至7天的再生肝组织中，cGMP浓度没有一致的变化，但cAMP浓度高于对照组。在出生后的生长过程中，出生后2至60天，脾脏、睾丸、肾皮质、肾乳头、肝脏或心室的cGMP浓度没有一致的变化。另一方面，除脾脏外，所有这些组织中的cAMP浓度在出生后第21天至40天之间降低，即在快速生长阶段。在脾脏中，cAMP浓度从出生后第二天到第五天持续增加。在处死前两日通过大剂量静脉注射叶酸诱导肾实质增生的过程中，肾皮质组织中的cGMP浓度持续增加。本文提出了一个模型来解释所发现的环核苷酸浓度的不同变化模式。
