Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan.
J Cardiol. 2011 Jul;58(1):38-45. doi: 10.1016/j.jjcc.2011.03.006. Epub 2011 May 26.
Pentraxin 3 (PTX3) is increased in circulating blood during the acute stage of acute coronary syndrome (ACS). Therefore, we compared diagnostic values of PTX3 for ACS with those of biomarkers for myocardial damage, such as troponin T (TnT) and heart-type fatty acid binding protein (H-FABP).
Patients (n = 87) undergoing coronary angiography (CAG), consisting of 16 ACS and 71 non-ACS patients were enrolled. Non-ACS consists of 12 patients with normal CAG, 30 stable angina pectoris (SAP) patients controlled by medical treatment, and 29 SAP patients who required elective coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft). Age, gender, or prevalence of diabetes, hypertension, or smoking was not significantly different between ACS and non-ACS groups. Serum total, high-density lipoprotein, or low-density lipoprotein cholesterol, or triglyceride levels were not significantly different between ACS and non-ACS. PTX3 levels were not significantly correlated with lipid profiles or different between those with and without conventional risk factors. Circulating PTX3, TnT, and H-FABP levels were significantly higher in ACS than non-ACS. In receiver-operating characteristic (ROC) curves, area under the curve (AUC) values for PTX3, TnT and H-FABP were 0.920, 0.674, and 0.690, respectively. ROC curves of PTX3 (AUC: 0.901), TnT (AUC: 0.731), and H-FABP (AUC: 0.633) for ST-elevation ACS were similar to those for whole ACS. In a TnT-negative subgroup, the AUC values of PTX3 and H-FABP for ACS were 0.981 and 0.489, respectively.
PTX3 is a sensitive and specific biomarker for the diagnosis of ACS, and shows additional diagnostic values when measured in combination with TnT.
在急性冠状动脉综合征（ACS）的急性阶段，循环血液中的 Pentraxin 3（PTX3）增加。因此，我们比较了 PTX3 对 ACS 的诊断价值与心肌损伤标志物（如肌钙蛋白 T（TnT）和心脏型脂肪酸结合蛋白（H-FABP））的诊断价值。
共纳入 87 例接受冠状动脉造影（CAG）的患者，包括 16 例 ACS 患者和 71 例非 ACS 患者。非 ACS 患者包括 12 例 CAG 正常患者、30 例经药物治疗控制的稳定型心绞痛（SAP）患者和 29 例需要择期冠状动脉血运重建（经皮冠状动脉介入治疗或冠状动脉旁路移植术）的 SAP 患者。ACS 组和非 ACS 组之间的年龄、性别或糖尿病、高血压或吸烟的患病率无显著差异。ACS 组和非 ACS 组之间的血清总胆固醇、高密度脂蛋白胆固醇或低密度脂蛋白胆固醇或甘油三酯水平无显著差异。PTX3 水平与血脂谱无显著相关性，且在有无常规危险因素的患者之间无差异。ACS 患者的循环 PTX3、TnT 和 H-FABP 水平显著高于非 ACS 患者。在受试者工作特征（ROC）曲线中，PTX3、TnT 和 H-FABP 的曲线下面积（AUC）值分别为 0.920、0.674 和 0.690。PTX3（AUC：0.901）、TnT（AUC：0.731）和 H-FABP（AUC：0.633）对 ST 段抬高型 ACS 的 ROC 曲线与对全 ACS 的 ROC 曲线相似。在 TnT 阴性亚组中，PTX3 和 H-FABP 对 ACS 的 AUC 值分别为 0.981 和 0.489。
PTX3 是 ACS 诊断的敏感和特异性生物标志物，与 TnT 联合测量时具有额外的诊断价值。
