Emergency Department, University Hospital Basel, Switzerland.
Dig Liver Dis. 2011 Sep;43(9):742-7. doi: 10.1016/j.dld.2011.04.014. Epub 2011 May 26.
Whether diabetes mellitus is associated with an increased risk of cholecystectomy remains controversial.
To explore the association between diabetes mellitus and the risk of cholecystectomy.
Population-based case-control analysis using UK-based General Practice Research Database. Cases of cholecystectomy and up to four controls per case, matched on age, sex, BMI, general practice, calendar time, and years of history in the database were identified between 1994 and 2008. Conditional logistic regression was used to estimate the risk of cholecystectomy in diabetics compared to non-diabetics. Odds ratios (ORs) were calculated, adjusted for smoking, alcohol consumption, statin use, and additional confounders.
Amongst 22,574 cases with cholecystectomy and 72,476 controls, 1068 (4.7%) and 3270 (4.5%) had diabetes, respectively, yielding an adjusted OR for developing gallstone disease followed by cholecystectomy of 0.88, 95% CI 78-1.00, p=0.05) in association with diabetes mellitus. Neither glycaemic control, nor increasing diabetes duration or oral antidiabetic therapies were associated with an altered risk of cholecystectomy. Use of statins was protective in patients with (adj. OR 0.66, 95% CI 0.54-0.80, p<0.0001) or without diabetes (adj. OR 0.70, 95% CI 0.62-0.78, p<0.0001).
Diabetes mellitus was not associated with an altered risk of cholecystectomy.
糖尿病是否与胆囊切除术风险增加相关仍存在争议。
探讨糖尿病与胆囊切除术风险之间的关系。
利用英国基于普通实践研究数据库的基于人群的病例对照分析。1994 年至 2008 年间，确定了胆囊切除术病例和每例病例最多 4 名对照，匹配年龄、性别、BMI、普通实践、日历时间和数据库中病史年限。采用条件逻辑回归估计糖尿病患者与非糖尿病患者相比胆囊切除术的风险。计算了比值比（OR），并调整了吸烟、饮酒、他汀类药物使用和其他混杂因素。
在 22574 例胆囊切除术病例和 72476 例对照中，分别有 1068 例（4.7%）和 3270 例（4.5%）患有糖尿病，调整后发生胆囊结石病继而行胆囊切除术的风险比为 0.88（95%CI78-1.00，p=0.05）与糖尿病相关。血糖控制情况、糖尿病持续时间或口服抗糖尿病药物的增加均与胆囊切除术风险的改变无关。他汀类药物的使用在有（调整后的 OR 0.66，95%CI 0.54-0.80，p<0.0001）或无糖尿病（调整后的 OR 0.70，95%CI 0.62-0.78，p<0.0001）的患者中具有保护作用。
糖尿病与胆囊切除术风险无相关性。
