Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
J Clin Rheumatol. 2011 Jun;17(4):197-200. doi: 10.1097/RHU.0b013e31821cb9d5.
We describe a case of antineutrophil cytoplasmic antibody-positive vasculitis from levamisole-tainted cocaine with concomitant cocaine-induced midline destructive lesions of the palate and nasal septum. The diagnosis was confirmed after extensive clinical, laboratory, pathologic, and radiographic testing. Timely recognition of this clinical entity is critical to avoid misdiagnosis and unnecessary treatment with potentially harmful cytotoxic agents. Given the high rate of levamisole contamination within the nation's cocaine supply, clinicians should be alerted to this emerging health threat.
我们描述了一例由掺有左旋咪唑的可卡因引起的抗中性粒细胞胞浆抗体阳性血管炎，同时伴有可卡因引起的鼻中隔破坏性病变和鼻隔穿孔。在进行了广泛的临床、实验室、病理和影像学检查后，确诊了该病例。及时识别这种临床实体对于避免误诊和不必要的使用潜在有害细胞毒性药物至关重要。鉴于左旋咪唑在全国可卡因供应中的高污染率，临床医生应该警惕这种新出现的健康威胁。
