Dr. Horst Schmidt Klinik, Ludwig-Erhard Str. 100, D-65199 Wiesbaden, Germany.
Oncol Rep. 2011 Aug;26(2):299-307. doi: 10.3892/or.2011.1319. Epub 2011 May 25.
Radiation therapy is a major therapeutic modality in the management of cancer patients. Over 60% of these patients receive radiotherapy at some point during their course of treatment and over 90% will develop skin reactions after therapy. Problematic wound healing in radiation-damaged tissue constitutes a major surgical difficulty and despite all efforts, irradiated skin remains a therapeutic challenge. This review provides an overview of the fundamental principles of radiation therapy with regards to the wound healing in normal and irradiated skin. Furthermore, it presents techniques that describe how to prevent and manage skin side effects as well as prospects that may improve cutaneous wound repair in general and in irradiated skin.
放射治疗是癌症患者治疗的主要方式之一。超过 60%的患者在治疗过程中的某个阶段接受放射治疗，超过 90%的患者在治疗后会出现皮肤反应。在放射损伤的组织中，伤口愈合不良是一个主要的手术难题，尽管已经做出了各种努力，但放射后的皮肤仍然是一个治疗挑战。本综述概述了放射治疗对正常皮肤和放射皮肤伤口愈合的基本原理。此外，它还介绍了一些技术，这些技术描述了如何预防和处理皮肤副作用，以及可能改善一般皮肤和放射皮肤的皮肤伤口修复的前景。
