• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Immunological response of nasopharyngeal carcinoma patients to the Epstein-Barr-virus-coded thymidine kinase expressed in Escherichia coli.

作者信息

Littler E, Newman W, Arrand J R

机构信息

Cancer Research Campaign Laboratories, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.

出版信息

Int J Cancer. 1990 Jun 15;45(6):1028-32. doi: 10.1002/ijc.2910450608.

DOI:10.1002/ijc.2910450608
PMID:2161795
Abstract

A bacterial expression system which produces large amounts of the Epstein-Barr-virus-coded thymidine kinase has been developed and used to produce protein for Western blot analysis of a number of human antisera. Interestingly, only sera from nasopharyngeal carcinoma (NPC) patients had any detectable IgA antibody which reacted with the EBV TK. These findings provided the basis for ELISA tests using a crude lysate of the E. coli cells expressing the EBV TK as target antigen. Sera from NPC patients showed high levels of IgA reactive antibodies in this test while other sera did not.

摘要

相似文献

1
Immunological response of nasopharyngeal carcinoma patients to the Epstein-Barr-virus-coded thymidine kinase expressed in Escherichia coli.
Int J Cancer. 1990 Jun 15;45(6):1028-32. doi: 10.1002/ijc.2910450608.
2
Use of antigen expressed in bacteria for detection of EBV-specific thymidine kinase antibodies in sera from patients with nasopharyngeal carcinoma.利用细菌中表达的抗原检测鼻咽癌患者血清中的EBV特异性胸苷激酶抗体。
J Med Virol. 1992 Nov;38(3):214-9. doi: 10.1002/jmv.1890380311.
3
Diagnosis of nasopharyngeal carcinoma by means of recombinant Epstein-Barr virus proteins.利用重组爱泼斯坦-巴尔病毒蛋白诊断鼻咽癌
Lancet. 1991 Mar 23;337(8743):685-9. doi: 10.1016/0140-6736(91)90275-t.
4
Detection of IgA against Epstein-Barr virus BZLF-1 replication activator (ZEBRA) in sera of nasopharyngeal carcinoma patients with a recombinant ZEBRA protein.用重组ZEBRA蛋白检测鼻咽癌患者血清中针对爱泼斯坦-巴尔病毒BZLF-1复制激活因子（ZEBRA）的IgA
Zhonghua Yi Xue Za Zhi (Taipei). 1999 Jun;62(6):350-5.
5
Single-assay combination of Epstein-Barr Virus (EBV) EBNA1- and viral capsid antigen-p18-derived synthetic peptides for measuring anti-EBV immunoglobulin G (IgG) and IgA antibody levels in sera from nasopharyngeal carcinoma patients: options for field screening.用于检测鼻咽癌患者血清中抗爱泼斯坦-巴尔病毒（EBV）免疫球蛋白G（IgG）和IgA抗体水平的EB病毒（EBV）EBNA1和病毒衣壳抗原-p18衍生合成肽的单检测组合：现场筛查选项
J Clin Microbiol. 2006 Apr;44(4):1459-67. doi: 10.1128/JCM.44.4.1459-1467.2006.
6
Antibodies to Epstein-Barr virus thymidine kinase: a characteristic marker for the serological detection of nasopharyngeal carcinoma.
Int J Cancer. 2001 Mar 1;91(5):692-7. doi: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1108>3.0.co;2-g.
7
Serum and salivary IgA antibodies against a defined epitope of the Epstein-Barr virus nuclear antigen (EBNA) are elevated in nasopharyngeal carcinoma.
Int J Cancer. 1990 Jun 15;45(6):1061-4. doi: 10.1002/ijc.2910450614.
8
Immune responses to Epstein-Barr virus lytic proteins in patients with nasopharyngeal carcinoma.鼻咽癌患者对爱泼斯坦-巴尔病毒裂解蛋白的免疫反应。
J Med Virol. 2004 Aug;73(4):574-82. doi: 10.1002/jmv.20128.
9
[Screening of dominant epitopes of antigens related to antibodies in the sera of patients with nasopharyngeal carcinoma].[鼻咽癌患者血清中与抗体相关抗原优势表位的筛选]
Ai Zheng. 2004 Sep;23(9):999-1004.
10
[Development of new methods for the diagnosis of nasopharyngeal carcinoma].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010 Feb;24(1):65-7.

引用本文的文献

1
Establishment and validation of a two-step screening scheme for improved performance of serological screening of nasopharyngeal carcinoma.建立和验证两步筛选方案，以提高鼻咽癌血清学筛查的性能。
Cancer Med. 2018 Apr;7(4):1458-1467. doi: 10.1002/cam4.1345. Epub 2018 Feb 25.
2
Murine gammaherpesvirus 68 lacking thymidine kinase shows severe attenuation of lytic cycle replication in vivo but still establishes latency.缺乏胸苷激酶的鼠γ疱疹病毒68在体内显示出裂解周期复制的严重减弱，但仍能建立潜伏感染。
J Virol. 2003 Feb;77(4):2410-7. doi: 10.1128/jvi.77.4.2410-2417.2003.
3
The BFRF1 gene of Epstein-Barr virus encodes a novel protein.
爱泼斯坦-巴尔病毒的BFRF1基因编码一种新蛋白。
J Virol. 2000 Apr;74(7):3235-44. doi: 10.1128/jvi.74.7.3235-3244.2000.
4
The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase.爱泼斯坦-巴尔病毒胸苷激酶不能磷酸化更昔洛韦或阿昔洛韦，与1型单纯疱疹病毒胸苷激酶相比，其底物特异性较窄。
Antimicrob Agents Chemother. 1998 Nov;42(11):2923-31. doi: 10.1128/AAC.42.11.2923.
5
Epstein-Barr virus nuclear antigen 1 linear epitopes that are reactive with immunoglobulin A (IgA) or IgG in sera from nasopharyngeal carcinoma patients or from healthy donors.与鼻咽癌患者或健康供体血清中的免疫球蛋白A（IgA）或免疫球蛋白G（IgG）发生反应的爱泼斯坦-巴尔病毒核抗原1线性表位。
J Clin Microbiol. 1991 Oct;29(10):2180-6. doi: 10.1128/jcm.29.10.2180-2186.1991.
6
Relationship between antibody production to Epstein-Barr virus (EBV) early antigens and various EBV-related diseases.针对爱泼斯坦-巴尔病毒（EBV）早期抗原的抗体产生与各种EBV相关疾病之间的关系。
Springer Semin Immunopathol. 1991;13(2):233-47. doi: 10.1007/BF00201471.