GN Ramachandran Knowledge Center for Genome Informatics, Institute of Genomics and Integrative Biology (CSIR), Mall Road, Delhi 110007.
Hum Mutat. 2011 Jun;32(6):E2226-45. doi: 10.1002/humu.21482. Epub 2011 Feb 24.
microRNAs are a recently discovered and well studied class of small noncoding functional RNAs. The regulatory role of microRNAs (miRNAs) has been well studied in a wide variety of biological processes but there have been no systematic effort to understand and analyze the genetic variations in miRNA loci and study its functional consequences. We have comprehensively curated genetic variations in miRNA loci in the human genome and established a computational pipeline to assess potential functional consequences of these variants along with methods for systematic curation and reporting of variations in these loci. The data is made available on the Leiden Open (source) Variation Database (LOVD) platform at http://genome.igib.res.in/mirlovd to provide ease of aggregation and analysis and is open for community curation efforts.
microRNAs 是一类新发现并得到深入研究的小型非编码功能 RNA。microRNAs（miRNAs）的调控作用已在广泛的生物学过程中得到深入研究，但尚未有系统的努力来理解和分析 miRNA 基因座中的遗传变异，并研究其功能后果。我们全面整理了人类基因组中 miRNA 基因座的遗传变异，并建立了一个计算管道，以评估这些变体的潜在功能后果，以及用于系统整理和报告这些基因座中的变体的方法。该数据可在 Leiden Open (source) Variation Database (LOVD) 平台上获得，网址为 http://genome.igib.res.in/mirlovd，以方便聚合和分析，并开放给社区进行整理。
