Department of Organic Chemistry, Faculty of Science, TWAS Research Unit of the University of Yaoundé I , P.O. Box 812, Yaoundé, Cameroon.
J Nat Prod. 2011 Jun 24;74(6):1370-8. doi: 10.1021/np100896w. Epub 2011 May 27.
Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A-C (1-3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC₅₀) 0.68 μM) showed inhibitory activity on β-glucuronidase enzyme, while 3 (IC₅₀) 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).
对榕属植物无花果的化学成分研究导致了三种新的异黄酮二聚体衍生物，即 mucusisoflavones A-C（1-3）的分离，以及 16 种已知化合物。一些分离物在体外对β-葡萄糖醛酸酶和恶性疟原虫烯酰基-ACP 还原酶（PfENR）酶的抑制活性进行了测试。化合物 1（IC₅₀）为 0.68 μM）对β-葡萄糖醛酸酶具有抑制活性，而 3（IC₅₀）为 7.69 μM）对恶性疟原虫烯酰基-ACP 还原酶（PfENR）表现出较弱的抑制活性。
