Fedor R, Asztalos L, Locsey L, Szabó L, Mányiné I S, Fagyas M, Lizanecz E, Tóth A
University of Debrecen, Medical and Health Science Center, Division of Clinical Physiology, Debrecen, Hungary.
Transplant Proc. 2011 May;43(4):1259-60. doi: 10.1016/j.transproceed.2011.03.064.
Kidney transplant recipients show a higher risk for cardiovascular complications, such as left ventricular hypertrophy and heart failure, leading to the premature death in many cases.
We investigated the contribution of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism to the development of left ventricular hypertrophy (LVH), an indicator of heart disease progression among kidney transplant recipients.
We observed a significant correlation between graft function and left ventricular mass index. The occurrence of LVH or severe LVH was significantly greater among patients with at least one D-allele (ID or DD).
The use of ACE inhibitors or angiotensin receptor blockers seemed to be advantageous for patients with the ID and especially, the DD genotype.
肾移植受者出现心血管并发症的风险较高，如左心室肥厚和心力衰竭，在许多情况下会导致过早死亡。
我们研究了血管紧张素转换酶（ACE）插入/缺失（I/D）多态性对左心室肥厚（LVH）发生的影响，LVH是肾移植受者心脏病进展的一个指标。
我们观察到移植肾功能与左心室质量指数之间存在显著相关性。至少携带一个D等位基因（ID或DD）的患者发生LVH或严重LVH的情况明显更多。
对于ID基因型尤其是DD基因型的患者，使用ACE抑制剂或血管紧张素受体阻滞剂似乎是有益的。
