Sampaio A M, Thomasini R L, Guardia A C, Stucchi R S B, Rossi C L, Costa S C B, Boin I F S F
Department of Medical Science, University of Campinas, Campinas, Brazil.
Transplant Proc. 2011 May;43(4):1357-9. doi: 10.1016/j.transproceed.2011.03.062.
Human herpesvirus (HHV)-6, HHV-7, and cytomegalovirus (CMV) that remain latent after primary infection can be reactivated during immunosuppression following organ transplantation in liver transplant recipients. The aim of this study was to monitor active infections for HHV-6, HHV-7, and CMV among adult liver transplantation recipients using antigenemia detected by an immunoperoxidase staining. Twenty-eight adult liver transplant patients were monitored using antigenemia in blood samples obtained at the time of transplantation, as well as weekly in the first month and once a month for 6 months. Of these patients, 28.5% showed positive CMV antigenemia; 39.2%, HHV-6 antigenemia; and 14.2%, HHV-7 antigenemia. The detection of the three viruses was considered to be independent of one another (P>.05). The results described above showed that few patients remain free of beta herpesviruses after liver transplantation. Most patients were infected sequentially and not concurrently. Antigenemia has been considered useful to detect active HHV-6 and HHV-7 infections. Antigenemia can be more efficiently interpreted when compared with polymerase chain reaction results, although other studies are necessary to establish the reference of HHV-6 and HHV-7 antigenemia.
人类疱疹病毒（HHV）-6、HHV-7和巨细胞病毒（CMV）在初次感染后会保持潜伏状态，在肝移植受者进行器官移植后的免疫抑制期间可能会被重新激活。本研究的目的是通过免疫过氧化物酶染色检测抗原血症，监测成年肝移植受者中HHV-6、HHV-7和CMV的活动性感染。对28例成年肝移植患者在移植时采集的血样进行抗原血症监测，在第一个月每周监测一次，在接下来的6个月每月监测一次。在这些患者中，28.5%显示CMV抗原血症阳性；39.2%显示HHV-6抗原血症阳性；14.2%显示HHV-7抗原血症阳性。这三种病毒的检测被认为是相互独立的（P>0.05）。上述结果表明，肝移植后很少有患者未感染β疱疹病毒。大多数患者是相继感染而非同时感染。抗原血症被认为有助于检测HHV-6和HHV-7的活动性感染。与聚合酶链反应结果相比，抗原血症的解读可能更有效，不过还需要其他研究来确定HHV-6和HHV-7抗原血症的参考标准。
