Department of Pathology and Molecular Medicine, McMaster University Medical Centre, McMaster University, 1200 Main St W, Hamilton ON, Canada.
Clin Biochem. 2011 Jul;44(10-11):767-70. doi: 10.1016/j.clinbiochem.2011.05.006. Epub 2011 May 18.
This study determined age specific, free thyroxine and thyroid stimulating hormone reference intervals for a pediatric population.
The data set was partitioned into age groups and the Tukey method was used to identify outliers for removal. The Harris and Boyd algorithm was used to determine if groups could be merged. Reference intervals were calculated using both non-parametric and robust methods. Boot-strapping was used to determine the 90% confidence intervals surrounding the upper and lower limits of each reference interval. These population based reference intervals were then compared to the manufactures suggested reference intervals.
This study provides non-parametric and robust reference intervals with associated 90% confidence intervals for free thyroxine and thyroid stimulating hormone as measured on the Roche Modular Analytics E 170.
The results emphasize the importance of establishing population-based reference intervals for the clinical laboratory.
本研究确定了儿科人群特定年龄的游离甲状腺素和促甲状腺激素参考区间。
数据集被分成年龄组，使用 Tukey 方法识别异常值并进行剔除。使用 Harris 和 Boyd 算法确定是否可以合并组。参考区间使用非参数和稳健方法计算。使用自举法确定每个参考区间上下限的 90%置信区间。然后将这些基于人群的参考区间与制造商建议的参考区间进行比较。
本研究提供了基于 Roche Modular Analytics E 170 测量的游离甲状腺素和促甲状腺激素的非参数和稳健参考区间，以及相关的 90%置信区间。
结果强调了为临床实验室建立基于人群的参考区间的重要性。
