脊椎动物肢体肌肉的起源：前体细胞和成肌细胞群体的作用。
Origin of vertebrate limb muscle: the role of progenitor and myoblast populations.
机构信息
Department of Human Genetics, University of Utah, Salt Lake City, Utah, USA.
出版信息
Curr Top Dev Biol. 2011;96:1-32. doi: 10.1016/B978-0-12-385940-2.00001-2.
Abstract
Muscle development, growth, and regeneration take place throughout vertebrate life. In amniotes, myogenesis takes place in four successive, temporally distinct, although overlapping phases. Understanding how embryonic, fetal, neonatal, and adult muscle are formed from muscle progenitors and committed myoblasts is an area of active research. In this review we examine recent expression, genetic loss-of-function, and genetic lineage studies that have been conducted in the mouse, with a particular focus on limb myogenesis. We synthesize these studies to present a current model of how embryonic, fetal, neonatal, and adult muscle are formed in the limb.
摘要
肌肉的发育、生长和再生贯穿于整个脊椎动物的生命过程。在羊膜动物中，成肌发生发生在四个连续的、时间上不同但又重叠的阶段。了解胚胎、胎儿、新生儿和成人肌肉如何由肌肉祖细胞和定向成肌细胞形成是一个活跃的研究领域。在这篇综述中，我们检查了最近在小鼠中进行的表达、基因功能丧失和遗传谱系研究，特别关注了肢体成肌发生。我们综合这些研究，提出了一个当前的模型，说明肢体中的胚胎、胎儿、新生儿和成人肌肉是如何形成的。
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