In vitro effect of transfer factor on the cyclic nucleotide level of human lymphocytes in chronic lymphocytic leukaemia and of mouse lymphocytes.

In the present study transfer factor (TF) failed to produce any change in the cAMP- and cGMP-levels of lymphocytes of patients with chronic lymphoid leukaemia (CLL). This is attributed to the malignant transformation of the lymphocytes or to a changed proportion of different lymphocyte populations in CLL. Human TF leaves the cyclic nucleotide levels of splenic lymphocytes of BALB/c mice unaffected.